Brief description of the Research Team / Research Group / Department
The B cell physiopathology team is part of a research ensemble recognized by the University (UCM) and validated in 2018 as excellent (91/100) by the AEI (https://www.ucm.es/grupos-deinvestigacion). It joined the Hospital 12 de Octubre Health Research Institute (Area 6: Inflammatory and immune disorders). Lymphocyte Immunobiology include 10 additional groups with shared interests, facilities and weekly lab seminars. IPs (topics): Regueiro JR, Fernandez-Malave E, Recio MJ, Cardenas PP (T cell physiopathology), Martínez-Naves E/Gómez del Moral M (antigen-presenting cells and molecules), Cabañas C/Lafuente EM (cell adhesion and intracellular signalling), Reche PA (immunomedicine/epitomics), Roda-Navarro P (immune synapse and intracellular signalling), Martínez-Quiles N (signal transduction and the cytoskeleton), Goicoechea de Jorge E/Tortajada A (microRNAs and complement physiopathology), Cubero FJ (liver injury and inflammation), Redondo-Muñoz J (cell migration and epigenetics) and Iborra S (Crosstalk between Dendritic Cells and T Lymphocytes).<br /><br /><br />The B cell physiopathology team is actually composed of two predoctoral students and a master student.
Research lines / projects proposed
The main interest of the group is the characterization of the role of microRNAs in the regulation of mature B cell biology and oncogenic transformation processes. Current research lines aim at characterizing two specific aspects about the functional contribution of miRNAs to oncogenic B cell transformation to identify novel therapeutic targets for Germinal Center (GC)-derived lymphoma treatment:<br /><br /> 1. To characterize molecular mechanisms underlying the tumor-suppressor properties of miR-28, a GC-specific miRNA whose expression is reduced in several types of primary B cell lymphomas that originate in GC B cells, including the aggressive Burkitt lymphoma (BL) and Diffuse Large B Cell Lymphoma (DLBCL).<br />2. To determine the impact of AID mutagenic activity on miRNA repertoire and its contribution to mature B cell transformation by promoting the escape from miRNA posttranscriptional gene expression regulation.