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Colonización, Microbioma y Patogénesis Fúngica

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Scientic Supervisor / Contact Person

Name and Surname
Jesús Pla Alonso

Localization & Research Area

Faculty / Institute
Faculty of Pharmacy
Microbiologia y Parasitologia
Research Area
Life Sciences (LIF)

MSCA & ERC experience

Research group / research team hosted any MSCA fellow?
Research group / research team have any ERC beneficiaries?

Research Team & Research Topic

Research Team / Research Group Name (if any)
Colonización, Microbioma y Patogénesis Fúngica
Website of the Research team / Research Group / Department
Brief description of the Research Team / Research Group / Department
Our group is involved in the analysis of host-pathogen interactions during fungal infection. We mainly use Candida albicans as model organism to explore fungal pathogenesis. Our work mainly focuses on the role that MAP kinase signal transduction pathways play in this microbe. We are interested determining the specificity of the stimuli, the responses generated and the interactions among these routes as well as the consequences of their activation. A better understanding of this complex system may be exploited for the design of new and novel antifungals. Experimental approaches and methodologies used in our research comprise molecular genetics, biochemistry, cell biology, genome wide strategies (transcriptomal and proteomic) and experimental infection in mice. Recently, we are using genetically modified strains disrupted in genes essential to pathogenesis to understand the mechanisms used by the immune system to control Candida infections. We are determining the key components (receptors and/or cytokines) that influence the decision of the host towards control (commensalism) or susceptibility to invasion (disease). We are also using model of commensalism in mice to define the role of certain host specific genes in susceptibility to infection. An envisioned short term goal of our group is to develop tools, strategies and methodologies to image in vivo a fungal infection.
Research lines / projects proposed
Genetic analysis of commensalism in the fungal pathogen Candida albicans
Development ofr CRISPR based approaches in Candida albicans
Development of genetic strategies to analyse fungal infections in vivo

Application requirements

Professional Experience & Documents
An updated Curriculum Vitae and and letter of interest are required.
You can attach the 'One Page Proposal' to enhance the attractiveness of your application. Supervisors usually appreciate it. Please take into account your background and the information provided in Research Team & Research Topic section to fill in it.

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