New mechanisms regulating neuropsychiatric disorders / Sheddome and Disease Lab
Scientic Supervisor / Contact Person
Name and Surname
Lola Martín-de-Saavedra
ORCID (link)
Localization & Research Area
Faculty / Institute
Faculty of Pharmacy
Department
Biochemistry and Molecular Biology
Research Area
Life Sciences (LIF)
MSCA & ERC experience
Research group / research team hosted any MSCA fellow?
No
Research group / research team have any ERC beneficiaries?
No
Research Team & Research Topic
Research Team / Research Group Name (if any)
Shedome and Disease Lab
Website of the Research team / Research Group / Department
Brief description of the Research Team / Research Group / Department
The Sheddome & Disease Lab is a dynamic and growing research group focused on understanding how ectodomain shedding regulates neuronal function and contributes to neuropsychiatric and neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. By investigating how proteolytic processing of membrane proteins generates bioactive signaling molecules, the lab addresses fundamental and timely questions at the interface of molecular neuroscience and disease.
The group combines in vitro and in vivo models with a multidisciplinary and cutting-edge methodological approach, integrating advanced biochemistry, molecular and cell biology, imaging, proteomics, and bioinformatics. This strategy enables the identification of novel mechanisms linking protein processing to synaptic function and neuronal communication.
The lab provides a collaborative and supportive research environment with a strong emphasis on scientific excellence, innovation, and career development. Postdoctoral researchers are encouraged to develop independent ideas while benefiting from close mentorship, access to diverse techniques, and opportunities for international collaboration. The overarching goal is to generate impactful discoveries that identifies new therapeutic strategies in brain disorders.
The group combines in vitro and in vivo models with a multidisciplinary and cutting-edge methodological approach, integrating advanced biochemistry, molecular and cell biology, imaging, proteomics, and bioinformatics. This strategy enables the identification of novel mechanisms linking protein processing to synaptic function and neuronal communication.
The lab provides a collaborative and supportive research environment with a strong emphasis on scientific excellence, innovation, and career development. Postdoctoral researchers are encouraged to develop independent ideas while benefiting from close mentorship, access to diverse techniques, and opportunities for international collaboration. The overarching goal is to generate impactful discoveries that identifies new therapeutic strategies in brain disorders.
Research lines / projects proposed
The successful candidate will join the Sheddome & Disease Lab to study how shedding of neurodevelopmental risk factors regulates neuronal function and contributes to neuropsychiatric disorders. The work will be conducted in the context of the Spanish Research Agency awarded project PID2024-156357OB-I00, which aims to uncover how proteolytic processing of membrane proteins influences synaptic communication and brain disease.
Research will focus on identifying shedding-regulated molecules and characterizing their impact on neuronal signaling and synaptic function using in vitro and in vivo approaches combined with biochemical, imaging, and -omics techniques.
Research will focus on identifying shedding-regulated molecules and characterizing their impact on neuronal signaling and synaptic function using in vitro and in vivo approaches combined with biochemical, imaging, and -omics techniques.
Key words
Application requirements
Professional Experience & Documents
We welcome applications from motivated candidates with a strong background in neuroscience, molecular biology, cell biology, or related disciplines. Prior experience with techniques such as induced pluripotent stem cell (iPSC) models, molecular cloning, or bioinformatics analysis will be considered an advantage, but is not mandatory. Candidates are expected to demonstrate scientific curiosity, critical thinking, and the ability to work both independently and collaboratively in an interdisciplinary environment.
Applicants should submit a curriculum vitae (CV), a letter of motivation outlining their research interests, and contact details for at least two academic references.
Applicants should submit a curriculum vitae (CV), a letter of motivation outlining their research interests, and contact details for at least two academic references.
One Page Proposal
You can attach the 'One Page Proposal' to enhance the attractiveness of your application. Supervisors usually appreciate it. Please take into account your background and the information provided in Research Team & Research Topic section to fill in it.
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