Research Team / Research Group Name (if any)
Signal Transduction and the Cytoskeleton
Brief description of the Research Team / Research Group / Department
During her period at Children"s Hospital (Harvard Medical School), the PI studied the signal transduction pathways of immunodeficiency called Wiskott-Aldrich syndrome. In previous studies, our research has focused on cortactin regulation using the model of infection enteropathogenic Escherichia coli (EPEC), which adheres to cells by forming actin pedestals. During this period, we established collaborations to study the role of cortactin in the infection of cells by Helicobacter pylori and by Coxiella. Another line of research developed has been the study of the regulation of cortactin by post-translational modifications and its role in cell spreading. Thus, we have characterized a novel cortactin-FAK complex that functions as a molecular clutch" in integrin activation. In addition, we found a competetion between the acetylation and tyrosine phosphorylation of cortactin and that phosphorylation inhibits cell spreading. Lately we have the great opportunity of collaborating to unravel the molecular mechanisms controlling exocytosis.<br /><br />"
Research lines / projects proposed
Currently, we are interested on mechanisms of cell motility underlying the immunological response, especially in autoinflammatory diseases. Thus, one major line of our research proteins such as Crk and Nck adaptors and signaling pathways mediated by the immune cortactin paralogue HS1 protein. <br />In addition, and thanks to a Fulbright-sponsored 6 months research visit to the National Institutes of Health (NIH) in Bethesda (MD, USA), we have stablished collaborative studies with Dr. Raphaela Goldbach-Mansky, chief of the Translational Autoinflammatory Diseases Section within the Laboratory of Clinical Immunology and Microbiology (LCIM) of the NIAID (National Institute of Allergy and Infectious Diseases).